High throughput toxicokinetics (“HTTK”) is the combination of in vitro data and generic mathematical models to predict absorption, distribution, metabolism, and excretion by the body, as decribed by Pearce et al. (2017) (doi:10.18637/jss.v079.i04) and Breen et al. (2021) (doi:10.1080/17425255.2021.1935867). We provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (doi:10.1371/journal.pone.0321321), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.
httk.vignettes()vignette("IntroToHTTK")John Wambaugh [John.Wambaugh@UL.org]
Robert Pearce, Caroline Ring [Ring.Caroline@epa.gov], Greg Honda [honda.gregory@epa.gov], Matt Linakis [MLINAKIS@ramboll.com], Dustin Kapraun [kapraun.dustin@epa.gov], Kimberly Truong [truong.kimberly@epa.gov], Annabel Meade [aemeade7@gmail.com], Celia Schacht [Schacht.Celia@epa.gov], and Elaina Kenyon